Biological Relevance Testing (brt)
Analyses of large-scale -omics datasets commonly use p-values as the indicators of statistical significance. However, considering p-value alone neglects the importance of effect size (i.e., the mean difference between groups) in determining the biological relevance of a significant difference. Here, we present a novel algorithm for computing a new statistic, the biological relevance testing (BRT) index, in the frequentist hypothesis testing framework to address this problem.

Finding Optimal Three-Group Splits Based on a Survival Outcome (rolr)
Provides fast procedures for exploring all pairs of cutpoints of a single covariate with respect to survival and determining optimal cutpoints using a hierarchical method and various ordered logrank tests.

Htmlwidgets’ in Responsive ‘iframes’ (widgetframe)
Provides two functions ‘frameableWidget()’, and ‘frameWidget()’. The ‘frameableWidget()’ is used to add extra code to a ‘htmlwidget’ which allows is to be rendered correctly inside a responsive ‘iframe’. The ‘frameWidget()’ is a ‘htmlwidget’ which displays content of another ‘htmlwidget’ inside a responsive ‘iframe’. These functions allow for easier embedding of ‘htmlwidgets’ in content management systems such as ‘wordpress’, ‘blogger’ etc. They also allow for separation of widget content from main HTML content where CSS of the main HTML could interfere with the widget.

Gradient and Vesselness Tools for Arrays and NIfTI Images (vesselr)
Simple functions capable of providing gradient, hessian, and vesselness for a given 3-dimensional volume.